As the worldwide death rate from hepatobiliary cancers continues to grow, Drs. Karasic and Loaiza-Bonilla explain that research must focus on finding an effective treatment—and immunotherapy could be the answer.
Dr. Jorge Gallardo and colleagues discuss the epidemiology of esophageal, gastric, liver, gallbladder, pancreatic, colon, and rectal cancers in Chile and how the country’s changing demographics across the past 20 years have increased cancer mortality rates.
Drs. Young and Chau review several early-phase studies on combination immunotherapy treatments for GI cancers and what these studies have uncovered about the certain tumor types that are responsive and those that are poorly immunogenic.
Drs. Kabir Mody (pictured) and Tushar Patel discuss recent advances in our understanding of the genomics of cholangiocarcinoma that offer new opportunities for more effective approaches to systemic therapies and could improve outcomes for patients with these cancers.
Dr. Robert S. Sandler questions the usefulness and benefits of colonoscopy in elderly patients, arguing the risks might outweigh the benefits. He advises that doctors should discuss with patients whether or not to continue screening after age 75 or if life expectancy is limited.